Chemical Proteomics Maps Brain Region Specific Activity of Endocannabinoid Hydrolases

نویسندگان
چکیده

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Focused ultrasound modulates region-specific brain activity

We demonstrated the in vivo feasibility of using focused ultrasound (FUS) to transiently modulate (through either stimulation or suppression) the function of regional brain tissue in rabbits. FUS was delivered in a train of pulses at low acoustic energy, far below the cavitation threshold, to the animal's somatomotor and visual areas, as guided by anatomical and functional information from magn...

متن کامل

Chemical proteomics reveals a second family of cyclic-di-AMP hydrolases.

Cyclic-di-AMP is a relative newcomer to the large family of nucleotide-based signaling molecules, which notably includes cyclic-AMP, cyclic-di-GMP, and ppGpp(p) (1). Cyclic-diAMP was first implicated as a possible signaling molecule when it was unexpectedly found bound to the active site of the Bacillus subtilis DisA protein, the prototype for a diverse family of diadenyl cyclases (DAC) (2). Sh...

متن کامل

Chemical strategies for activity-based proteomics.

The assignment of molecular and cellular functions to the numerous protein products encoded by prokaryotic and eukaryotic genomes presents a major challenge for the field of proteomics. To address this problem, chemical approaches have been introduced that utilize small-molecule probes to profile dynamics in enzyme activity in complex proteomes. These strategies for activity-based protein profi...

متن کامل

Chemical probes of endocannabinoid metabolism.

The endocannabinoid signaling system regulates diverse physiologic processes and has attracted considerable attention as a potential pharmaceutical target for treating diseases, such as pain, anxiety/depression, and metabolic disorders. The principal ligands of the endocannabinoid system are the lipid transmitters N-arachidonoylethanolamine (anandamide) and 2-arachidonoylglycerol (2-AG), which ...

متن کامل

Hydrolases in Developing Rat Brain

It is not yet clear whether lysosomal enzymes act only in degenerative processes, in response to noxious stimuli, or whether they act in the normal degradative processes of turnover. In support of the latter belief is the observation that specific lysosomal enzymes are absent (or highly deficient) in certain genetic lesions characterized by accumulation of the intermediates on which they act 6,...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: ACS Chemical Biology

سال: 2017

ISSN: 1554-8929,1554-8937

DOI: 10.1021/acschembio.6b01052